G-Quadruplexes at Telomeres: Friend or Foe?
Telomeres are DNA-protein complexes that cap and protect the ends of linear chromosomes.In almost all species, telomeric DNA has a G/C strand bias, and the short tandem repeats of the G-rich strand have the capacity to form into secondary structures in vitro, such as four-stranded G-quadruplexes.This has long prompted speculation that G-quadruplexe